;(21)– [PubMed]; Constantopoulos A, Karpathios T, Nicolaidou P, Maounis F, Matsaniotis N. Lazy-leukocyte syndrome. A case report . The lazy leukocyte syndrome was first described by Miller et al. in in two children with recurrent infection. They had normal humoral and cellular immunity . – LAZY LEUKOCYTE SYNDROME. LAZY LEUKOCYTE SYNDROME. Clinical Synopsis Toggle Dropdown. Inheritance. -? Autosomal dominant new.

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Miller knew of 4 other cases. A severe neutropenia was found. Mobilization of leukocytes after exercise was defective. Single cases were reported by Costanopoulos et al.


The same abnormality probably symdrome to impaired deformability of neutrophils so that release of newly formed neutrophils from the bone marrow is reduced. Expert curators review the ldukocyte and organize it to facilitate your work. Leukocyte phagocytosis and bactericidal activity were normal. A bonus to all MIMmatch users is the option to sign up for updates on new gene-phenotype relationships. A characteristic abnormality of actin distribution in neutrophils was demonstrated. Relative to the genetics and the possibility that these cases represent new dominant mutations, parental age data would be of interest.


Lazy leukocyte syndrome.

Pathology of chemotaxis and random mobility. We are determined to keep this website freely accessible. A new disorder of neutrophil function. We need long-term elukocyte funding to provide you the information that you need at your fingertips.

Lazy leukocyte syndrome | definition of lazy leukocyte syndrome by Medical dictionary

OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to synddome questions.

Skin window mobilization test and chemotaxis were normal. None is familial and no parental consanguinity is known. Please consider making a donation now and again in the future.

lazy leukocyte syndrome

Autosomal dominant new mutations. Looking For More References?

The year-old proposita had neutropenia and an illness suggestive of persistent Epstein-Barr virus infection. The syndrome is distinguished from neutrophil chemotactic deficiencies ,eukocyte the coexistence of defective random motility and peripheral blood neutropenia with normal bone marrow granulocyte reserve. Bone marrow studies showed normal numbers of mature, morphologically normal neutrophils.


Transient ‘lazy-leukocyte’ syndrome during infancy. Both random mobility and chemotactic function were defective. Leukoctte Synopsis Toggle Dropdown. Unfortunately, it is not free to produce.

A poor neutrophil response was obtained upon stimulation with both epinephrine and endotoxin, as well as upon induced inflammation by kazy Rebuck skin window technique.