Capitulo 1 – Download as PDF File .pdf), Text File .txt) or read online. Introducao-Bioestatística – Uploaded by. by Deborah Rumsey and if you can read in portuguese: Introdução a Bioestatística para simples mortais, by Ulysses Doria Filho) and take my. . -assassinos-e-poetas-que-sonharam-a-independencia-do-brasil-pedro-doria .

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There it is, nebulized and intravenous are the same? So, if I begin with polimyxin and just after 3 days add amikacin, this guy who recive amikacin is the same that our 5th day drunk guy. If you do agree, read the literature we have available today about combination therapy. From a statistical point of view, the drinker only begin to exist at day In their majority, the most cited, are observational trials.

Meaning, if you wanna treat them, do aa with the right dose!

Both groups with combined therapy had more infections caused by Klebsiella pneumoniae and Pseudomonas aeruginosas when the monotherapy group more Acinetobacter baumannii infections. Now, to study Klebsiella pneumoniae carbapenemase Gen2 causing blood doriaa infection and compare between monotherapy vs combined therapy? This is gonna be a revolving theme here, so keep your eyes open!

Nothing but the whole truth.

Combination therapy for non-believers, and believers too! – ICU Revisited

Because he had to survive our attempts to kill him as intensivists until day 5. This was a unicentric, retrospective study that from evaluated antibiotic combinations to guide therapy in patients with extensively drug-resistant gram negative bacilli XDR GNB infections of any site.


One interesting fact is that even with lot of difference among polymyxin doses no difference in nephropathy RIFLE was showed. Is that honest to compare this group with others? But after a multivariate analysis the authors throw the results saying the risk of infection related mortality is 8x greater in MT group and 6x greater in NVCT group when compared to VCT group.

The ART trial and how lung recruitment died. Why I hate tramadol but sometimes use it. And also other strange things happened. Combination therapy for non-believers, and believers too!

Therefore, beer drinkers have lower mortality than sober patients. Is the HCAP concept a lie? I agree that is not easy to study the same bacteria, dotia example, Klebsiella pneumoniae carbapenemase Gen2. Go hit the books then.

Even if the patients in the VCT group were more sick, it was the only group which received adequate dose treatment. Bioestatistlca primary outcome was infection related mortality, which was determined by the attending physician another bias here.

Combination therapy for non-believers, and believers too!

Another thing is to realize that the study compares different sites of infection and different bacterias. Take another look at the antibiotics doses table. Moving on… The eligible patients were divided in bioestatisica groups: The only group which received polymyxin at adequate dose was the VCT group. S Army — Delta associates — Memegenerator.

Escritos de Fernando Macedo e Thais Barros: Palavras 2

Recently I did a review of literature about combination therapy for multi-drug resistant bacterias and soon you will see here. Data and results Patients in the validated polymyxin combination therapy had more severe infections and more serious disease, monotherapy group was older.


I can show you that a patient who drinks beer at 5th day of ICU have lower mortality than a patient who does not. The median of adequate treatment for monotherapy group was ZERO!

The antibiotic dose was included in the multivariate model. Interestingly, was considered polymyxin use any of: Therefore, if you read an article showing a possible association between combined therapy and lower mortality and take this as true I can recommend you two books Statistics for Dummies, by Deborah Rumsey and if you can read in portuguese: Here we have a problem, Immortal Time Bias.

To begin with, I can do an observational trial, either retrospective or prospective, showing that doctors who drink wine 7 days a week have more sex.

For me the idea of using lower doses to avoid adverse affects might increase bacterial resistance. Keep this in mind! Patients in the validated polymyxin combination therapy had more severe infections and more serious disease, monotherapy group was older. All these information makes me wonder about the results of the multivariate analysis. Patients were included if: