Giant-cell arteritis (GCA) is a systemic inflammatory vasculitis of unknown etiology commonly Horton’s disease is a clinical entity caused by GCA mainly of temporal arteries (temporal arteritis). . Hunder GG, Bloch DA, Michel BA, et al. Dr. med.,3 and Peter Lamprecht, Prof. .. in acute temporal arteritis, showing hypoechoic wall thickening (arrows), .. Horton BT, Magath TB, Brown GE. Horton was a member of the International Cluster Headache Research Group from .. Horton emphasized that temporal arteritis is not a localized disease confined to the .. Musings on medical research with a note on my last talk with Dr. Will.

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Stenosis or vascular occlusion may be seen, resulting from the vascular inflammation. Cancer risk in patients hospitalized with polymyalgia rheumatica and giant cell arteritis: The cause is unknown. The area adjacent to the vessel may be edemaciated. Ferri’s Differential Diagnosis E-Book: Low-dose aspirin and prevention of cranial ischemic complications in giant cell arteritis. While the ophthalmic and ciliary posterior arteries contain a moderate quantity of elastic tissue, the retina central artery doesn’t contain much elastin, mainly when it penetrates the optical nerve sheath, and specially after perforating the nerve substance 9.

Since this morning, she has noticed a loss of the lower half of the visual field in the left eye, with loss of visual acuity. Inflamed temporal artery with intimal edema, cellular infiltration, and fragmented internal elastic membrane; box: Diabetes mellitus type 1 Hashimoto’s thyroiditis Multiple sclerosis Coeliac disease Giant-cell arteritis Postorgasmic illness syndrome Reactive arthritis. In the initial phase, the exam may reveal only subtle changes such as soreness upon the artery palpation.

Epidemiology The Horton’s Disease is the temloral prominent vasculitis in adults older than 50 years, with peak of incidence between 70 and 80 years 3and it’s of about cases per It affects cranial arteries, the aorta, and arteries elsewhere in the body, e. The inflammatory process typical of giant cells arteritis is generally superposed to the arteriosclerotic changes found in adults and old-aged. Diagnosis and treatment of giant cell arteritis.


In patients with a severe form of the disease and at high risk of prolonged therapy, adverse events of corticosteroids therapy are often observed. Tapering may require two or more years. At the same time, PET arterjtis a large scan volume, so that it is particularly suitable for whole body screening.

In this way, a picture of the whole pattern of cranial trmporal can be gained.

ds General manifestations, such as a moderate fever, vertigo, bruits, fatigue and malaise may also be present [ 45 ]. It is more common in women than in men by a ratio of 2: A number of diseases whose symptoms and findings overlap with those of GCA should be included in the differential diagnosis headache of other origin, unexplained raised ESR, other forms of vasculitis, polymyositis, non-arteritic AION, endocarditis.

Giant-cell arteritis

Superficial temporal artery biopsy”. Temporal artery biopsy is still regarded as the diagnostic gold standard for GCA. Pathophysiology, Clinical Aspects and Therapeutic Approaches. The frontal branch of the superficial temporal artery shows bilateral signs of wall inflammation thickening, uptake of contrast agent solid arrow.

Boesen P, Sorensen SF. In treatment, a high dose of corticosteroids methylprednisolone was administered, what gave relief of inflammation and diminished tumors of the temporal artery on the head and pain relief within a few days Figure 2. Most patients report constant pain in the temporal region. Journal List Dtsch Arztebl Int v.

The patient feels pain when he chaws or talk longer and improves with rest and it occurs in cases where there is facial artery involvement. Archived from the original on Two to six times more women are affected than men. The Johns Hopkins Vasculitis Center. Am J Emerg Med. Histologically, GCA is horon by inflammatory infiltration of the arterial wall by lymphocytes, macrophages, and giant cells Figure 4.


The Diagnosis and Treatment of Giant Cell Arteritis

A randomized, multicenter, controlled trial using intravenous pulses of methylprednisolone in the initial treatment of simple forms of giant cell arteritis: How long is the estimated average duration of medical treatment for giant cell arteritis? Laboratory tests revealed leukocytosis white blood cells WBC Bitemporal accentuated headaches refractory to analgesia occur in about three quarters of patients 3.

Especially feared is the silent or occult form of GCA, in which loss of vision is the first symptom 11e Correlations between histopathological findings and clinical manifestations in biopsy-proven giant cell arteritis.

The thyroid hormones were within the normal limits. These two investigations are non-specific, but are sensitive enough for everyday clinical routine ESR: Treatment is typically with high doses of steroidsarteirtis as prednisone. The mean age of onset is above 55 years, and it is rare in people aged less than 55 years. ESR, erythrocyte sedimentation rate. A stronger knowledge about the beginning, development and diagnosis of the temporal arteritis will contribute for the treatment evolution and possibility of more satisfactory prognoses.